Nootropics

http://www.erowid.org/smarts/smarts_faq.shtml
{pi -> ani + prami}racetam, hydergine, vasopressin

http://www.unfinishedman.com/nootropics-facts-about-smart-drugs/
choline
reverse acetyl-choline-sterase inhibitors: galantamine, huperzine A (more sparky plug)
Vasodilators and metabolic enhancers
Stimulants
Racetams

http://corpina.org/extreme-nootropics-big-guns-cognitive-enhancement/
extreme nootropics: Desmopressin, PKR Inhibitors, Cerebrolysin

SELLERS
http://advancenootropics.com/
http://peaknootropics.com/
https://www.intellimeds.co.uk/

Good Wiki
http://psychology.wikia.com/wiki/Nootropic_drugs

My forum posts:
http://www.drugs-forum.com/forum/showthread.php?t=243848
http://www.mindnutrition.com/forum/threads/557-Nootropic-stack-for-learning-perfect-pitch?p=5677#post5677
http://www.longecity.org/forum/topic/71525-searching-nootropic-stack-to-assist-learning-of-perfect-pitch/
Autism: A Critical Period Disorder?

^ links to http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2992973/
Valproic Acid, benzodiazepines,
Histone deacetylase (HDAC) inhibitors promote synaptic plasticity (Levenson and Sweatt, 2006), reactivate critical periods and rescue amblyopia in adult rodents
fluoxetine == PROZAC! no prescription needed, cholinesterase inhibitors,

Sodium Valproate reopens critical-period learning of absolute pitch

Sodium Valproate 5p but need prescription :/ —> http://www.pharmacy2u.co.uk/productdetailpom.aspx?packid=65042

Sunifiram — Enhance LTP
http://www.amazon.com/Sunifiram-DM-235-Grams-Pure-FBLM/dp/B00C7CF6RG 2g / $15

Noopept — LGF, X-Hemisphere; boost A/C synth
https://liftmode.com/noopepttm-gvs-111-10-grams-0-35-oz-98-pure-fblm.html 10g / $18

Sulbutiamine — Inc. Thiamine -> Brain (gives insomnia)
Phenibut — GABA inhibitor

Picamilon — GABA progenitor, "Certain pro-drugs of GABA (ex. picamilon) have been developed to permeate the blood brain barrier, then separate into GABA and the carrier molecule once inside the brain. This allows for a direct increase of GABA levels throughout all areas of the brain, in a manner following the distribution pattern of the pro-drug prior to metabolism."

OxiRacetam — LTP, > Ani & Prami

huperzine A — acetylcholinesterase-inhibitor, so inc A/C

NSI-189, hiccocampus + 20%, alibaba

- - -

http://en.wikipedia.org/wiki/Brain-derived_neurotrophic_factor

Sodium Valproate is HDAC Inhibitor http://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor <— also GABA blocker (ValproatePitch paper)
"Research has shown that inhibition of HDAC can reopen critical-period neuroplasticity in adult mice to enable recovery from amblyopia (Putignano et al., 2007; Silingardi et al., 2010), and to facilitate new forms of auditory learning (Yang et al., 2012)."

http://www.drugs-forum.com/forum/showthread.php?t=70245#ixzz36QKwzZV9
"PIR-nootropics have been combined in many clinical and experimental situations with other drugs, almost always with a positive, synergistic effect. Many clinical experiments have demonstrated PIR and OXR to synergise with anti-epileptic medications, especially carbamazepine (Tegretol)."

GABA inhibits firing. So a GABA-inhibitor (e.g. Benzodiazepine http://www.drugs-forum.com/forum/showwiki.php?title=Benzodiazepine) INCREASES firing.

http://peaknootropics.com/how-do-nootropics-work/

TO READ:
http://brainmeta.com/forum/index.php?showtopic=23657
http://www.mindandmuscle.net/forum/25174-nootropic-stack-facilitate-learning-programming-language-s


Stocked by these AliBaba people:

sunifiram
Unifiram — related.

http://www.adriancox.com/category/nootropics/ <— sunifiram modafinil
Suni "Ampakines work to improve the functioning of the AMPA neurological receptor, which enables faster and clearer signal transmission speed across synapses. It also works to enhance long-term potentiation- the process by which we go about learning or remembering anything."

"Some work well when I would like to zone into a work project on a computer (oxiracetam and modafinil), while others enhance creativity, music, and color saturation (aniracetam). As I do a lot of teaching and training, I like to enhance verbal acuity which seems to be accentuated by using piracetam."

MODAFINIL: (http://www.theguardian.com/education/mortarboard/2013/may/31/is-modafinil-safe-in-long-term) …"Modafinil definitely affects the dopamine system and dopamine will make you more alert, and also more interested in things," he says. "It affects norepinephrine which can again make you more alert and better able to focus, and it also affects histamine which can keep you awake." But it is modafinil's boost to the working memory that interests many, in particular students engaged in last-minute cramming. It is believed to enhance the short-term memory by as much as 10%, through its influence on a neurotransmitter called glutamate.

Coluracetam
Phenylpiracetam — Russian astronauts take it. Tolerance builds quickly.

noopept
Oxiracetam
Aniracetam

Fasoracetam <— ?? Hardly any information on this
Phenibut <— GABA inhibitor, withdrawal symptoms fast, anxiolytic, doesn't sound very interesting

Centrophenoxine
Centrophenoxine is an ester of DMAE and pCPA, it's a cholinergic compound
Neuroprotective (reduction of lipofuscin, a build up of Potassium that causes brain cells to be less efficient and die)
Enhance memory formation. Incr. brain's Oxygen&Glucose uptake.
Incr. RNA which are used by neurons to create protein which is used to encode memory and mend damaged cells in the brain.
1/2 g per day = 20p (ebay)


Oxiracetam
GOOD SITE: http://examine.com/supplements/Oxiracetam/ <— oxi + nicotine == yes

CHOLINE SYSTEM
http://examine.com/supplements/Cholinergic/

http://examine.com/supplements/Centella+asiatica/
cause an increase in neuronal growth (not how many neurons there are, but how far their dendrites branch out…)

GOOD THREAD:
http://www.longecity.org/forum/topic/57942-prl-8-53;-was-prl-8-147-the-most-powerful-memory-enhancer/page-49#entry622978
"Would you consider a combo of NSI-189, Dihexa, 7,8 dihydroxyflavone, Isoxazole-9 and possibly cerebrolysin the holy grail of adult neurogenesis at this point in time?"

http://www.human-memory.net/brain_neurons.html

http://www.longecity.org/forum/topic/67667-78-dihydroxyflavone/ —> BTW, if someone should run out of money he/she could try butyric acid supplements, which raise BDNF expression in an epigenetic way.

http://en.wikipedia.org/wiki/Transcranial_direct-current_stimulation
http://en.wikipedia.org/wiki/Histone_deacetylase_inhibitor#HDAC_classification <— 5 levels of HDACi

https://trubrain.com/blend

http://cercor.oxfordjournals.org/content/10/10/963.long <— Dendrite Growth

http://www.ncbi.nlm.nih.gov/pubmed/22211685 "GT polyphenols can have a promising role in the reversal of age-related loss of neuronal plasticity and recovery after neuronal lesions associated with aging."

DIHEXA
http://www.longecity.org/forum/topic/59312-dihexa-it-would-take-10-million-times-as-much-bdnf-to-get-as-much-new-synapse-formation-as-dihexa/
http://www.ncbi.nlm.nih.gov/pubmed/23055539
medicalxpress.com/news/2012-10-prospective-alzheimer-drug-brain-cell.html
(EnLilaSko) Dose is about 20 mg
http://www.reddit.com/r/Nootropics/comments/29rxw2/small_amount_of_dihexa_available/

LostFALCO
http://www.longecity.org/forum/topic/63228-lostfalcos-extensive-nootropic-experiments/

FGL
http://www.longecity.org/forum/topic/65934-fgl-ncam-derived-fgf-peptide-sparks-synaptic-plasticity-promotes-ltp-and-improves-memory-in-rodents/page-3

http://www.longecity.org/forum/topic/70513-gene-with-a-strong-link-to-intelligence-found/
http://www.longecity.org/forum/topic/63228-lostfalcos-extensive-nootropic-experiments/page-67#entry662273
^same content
Tributyrin should be studied further since it works very similar to trichostatin A as mentioned earlier. Can anyone point out the downsides of tributyrin specifically? People have noted how quickly butyrate is metabolised, but it seems tributyrin has much better pharmokinetics and the other interesting thing is that tributyrate is sold as a food grade flavor?! 10kg for 200 British pounds? Am I mistaken? Apparently it's naturally present in butter as well.

*http://www.dnalc.org/resources/3d/**
http://www.longecity.org/forum/topic/71918-hdac-inhibitors/

http://www.alibaba.com/product-detail/bulk-supply-99-nootropics-Coluracetam-Pramiracetam_1467274248.html
^ all HHD PHARM products

VIDS
DNA: https://www.youtube.com/watch?v=qy8dk5iS1f0&list=PL120FB0C1D188A018&index=3
^ from https://www.youtube.com/user/ppornelubio/videos <— more!

https://www.youtube.com/watch?v=eYrQ0EhVCYA <— HAT vs HDAC voice
https://www.youtube.com/watch?v=9QBigM8pKcM <— same but music

https://www.youtube.com/user/cellsignaldotcom/videos <— EPiGenetics — NICE!! (also do stem-cells)
https://www.youtube.com/watch?v=9AfBsTAQ8zs <— epi diet before birth
https://www.youtube.com/watch?v=N2LbVMcQbLk <— actually for a specific medicine but good CHROMATIN OPENER video!

https://www.youtube.com/watch?v=SHpfkNRscOc <— 40:30 HDACi
https://www.youtube.com/watch?v=yQ-GvPJH8T4 <— HDACi + SAHA

https://www.youtube.com/watch?v=mHak9EZjySs
^ 'X Inactivation and Epigenetics' 11 min — explains tortoiseshell cats

https://www.youtube.com/watch?v=P4ooV7z9rC0 <— Proper course!

https://www.youtube.com/watch?v=29doT6Hf2MI <— HDAC 1min

https://www.youtube.com/watch?v=mDZLiZB0iPY <— WHEI movies; cell division through DNA replication, using some of the above videos: 12 minutes

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